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KMID : 0370220220660050292
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Yakhak Hoeji
2022 Volume.66 No. 5 p.292 ~ p.301
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Cost-effectiveness of Combination Therapy of Anticoagulants/antiplatelets with Proton Pump Inhibitors: A Systematic Review
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Lee Yeon-Woo
Kwon Sun-Hong
Kim Na-Hyun
Lee Eui-Kyung
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Abstract
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Anticoagulants/antiplatelets are effective in preventing cardiovascular diseases (CVDs). However, as an adverseeffect, the risk of upper gastrointestinal bleeding (UGIB) leads to additional costs due to increased treatment and decreasedquality of life. Accordingly, the administration of proton pump inhibitors (PPI) is recommended to prevent UGIB. Weconducted a systematic review of economic evaluations of PPI co-therapy for patients taking long-term anticoagulants/antiplatelets to prevent CVDs to examine the cost effectiveness of PPI co-therapy. We searched literature from PubMedand EMBASE with keywords including types of economic evaluations and active ingredients of anticoagulants andantiplatelets on 13/07/2022. Two independent reviewers conducted a systematic review. As a result, six economicevaluation studies were identified. All studies compared PPI co-therapy with low-dose aspirin to prevent CVDs. Weconfirmed the cost-effectiveness of PPI co-therapy with the respective incremental cost-effectiveness ratio (ICER) in eachbase case. In the sensitivity analyses, the PPI cost and adherence influenced the ICER the most. The quality of reporting,which was assessed using the Consolidated Health Economic Evaluation Reporting Standards checklist, was 87-96%. Inthe present study, we found that PPI co-therapy was cost-effective and tended to improve the patient’s life years andquality-adjusted life years. These results can be used as evidence for further economic evaluation studies to verify the costeffectivenessof anticoagulants/antiplatelets and PPI co-therapy.
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KEYWORD
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Systematic Review, Economic Evaluation, Anticoagulants, Antiplatelets, Proton pump inhibitors
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